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    Genetic variation in the ABCB1 gene associated with post treatment lyme disease syndrome status

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    Author
    Lyon, J.
    Seung, H.
    Date
    2019
    Journal
    Meta Gene
    Publisher
    Elsevier B.V.
    Type
    article
    
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    https://doi.org/10.1016/j.mgene.2019.100589
    Abstract
    Post Treatment Lyme Disease Syndrome (PTLDS) poses a difficult to understand health issue. This multi-centered, randomized control trial studied the possible correlation between ABCB1 (MDR1) gene variants and the incidence of PTLDS in affected patients. Genomic DNA was isolated and analyzed for four ABCB1 gene SNPs (rs1128503, rs1045642, rs2235067, and rs4148740). Significant findings include the association of rs1128503 TC variant with PTLDS status. Additionally, the rs1128503+ rs1045642+ rs2235067 SNP combination increased rs1128503 genotype TC significance to 3.83 times the rs1128503 genotype CC. The TT variant of rs4148740 in conjunction with rs1128503 reduced the odds ratio and appeared to convey a PTLDS protective status to the rs1128503 TC variant. Copyright 2019 The Authors
    Sponsors
    This study was funded by a research grant from the Lyme Disease Association , Inc.
    Keyword
    ABCB1
    Genetics
    Lyme disease
    MDR1
    P-glycoprotein (P-gp)
    Post treatment lyme disease syndrome (PTLDS)
    rs1045642
    rs1128503
    rs2235067
    rs4148740
    Single nucleotide polymorphism (SNP)
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    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066934446&doi=10.1016%2fj.mgene.2019.100589&partnerID=40&md5=5b15563b2a7b1f634a28ab103059d95a; http://hdl.handle.net/10713/10174
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.mgene.2019.100589
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