Advanced cell therapeutics are changing the clinical landscape: Will mesenchymal stromal cells be a part of it?
Date
2019Journal
BMC MedicinePublisher
BioMed Central Ltd.Type
article
Metadata
Show full item recordAbstract
During the past 15 years there have been dramatic changes in the medical landscape, particularly in oncology and regenerative medicine. Cell therapies have played a substantial part in this progress. Cellular immunotherapies can use immune cells, such as T cells or natural killer cells that, after functional modification ex vivo, exert powerful anti-cancer effects when given to the patient. Innovative technologies, such as re-programming terminally differentiated cells into pluripotent stem cells or into other cell types and applying specific enzymes to more precisely edit the human genome, are paving the way towards more potent cell and gene therapies. Mesenchymal stromal cells are promising cellular immunotherapeutics, which also have potential for use in tissue engineering strategies and other regenerative medicine applications. However, substantial gaps in our knowledge of their biology and therapeutic efficacy present major challenges to their sustainable implementation in the clinical routine. In this article, progress in the field of cell therapeutics during the past 15 years will be briefly discussed, with a focus on mesenchymal stromal cells, highlighting the impact of this field on patient care. Copyright 2019 The Author(s).Keyword
BiotechnologyCell therapy
Immunotherapy
Mesenchymal stromal cells
Regenerative medicine
Stem cells
Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062416900&doi=10.1186%2fs12916-019-1289-6&partnerID=40&md5=8844b451a409e903cbad516c903ee028; http://hdl.handle.net/10713/10166ae974a485f413a2113503eed53cd6c53
10.1186/s12916-019-1289-6
Scopus Count
Collections
Related articles
- Understanding and leveraging cell metabolism to enhance mesenchymal stem cell transplantation survival in tissue engineering and regenerative medicine applications.
- Authors: Salazar-Noratto GE, Luo G, Denoeud C, Padrona M, Moya A, Bensidhoum M, Bizios R, Potier E, Logeart-Avramoglou D, Petite H
- Issue date: 2020 Jan
- Translational Cell Therapies in Regenerative Medicine and Cancers.
- Authors: Lin SZ
- Issue date: 2016
- Artificial intelligence: A joint narrative on potential use in pediatric stem and immune cell therapies and regenerative medicine.
- Authors: Sniecinski I, Seghatchian J
- Issue date: 2018 Jun
- Regeneration of cartilage and bone by defined subsets of mesenchymal stromal cells--potential and pitfalls.
- Authors: Aicher WK, Bühring HJ, Hart M, Rolauffs B, Badke A, Klein G
- Issue date: 2011 Apr 30
- Translational strategies and challenges in regenerative medicine.
- Authors: Dimmeler S, Ding S, Rando TA, Trounson A
- Issue date: 2014 Aug