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    Advanced cell therapeutics are changing the clinical landscape: Will mesenchymal stromal cells be a part of it?

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    Author
    Schäfer, R.

    Date
    2019
    Journal
    BMC Medicine
    Publisher
    BioMed Central Ltd.
    Type
    article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1186/s12916-019-1289-6
    Abstract
    During the past 15 years there have been dramatic changes in the medical landscape, particularly in oncology and regenerative medicine. Cell therapies have played a substantial part in this progress. Cellular immunotherapies can use immune cells, such as T cells or natural killer cells that, after functional modification ex vivo, exert powerful anti-cancer effects when given to the patient. Innovative technologies, such as re-programming terminally differentiated cells into pluripotent stem cells or into other cell types and applying specific enzymes to more precisely edit the human genome, are paving the way towards more potent cell and gene therapies. Mesenchymal stromal cells are promising cellular immunotherapeutics, which also have potential for use in tissue engineering strategies and other regenerative medicine applications. However, substantial gaps in our knowledge of their biology and therapeutic efficacy present major challenges to their sustainable implementation in the clinical routine. In this article, progress in the field of cell therapeutics during the past 15 years will be briefly discussed, with a focus on mesenchymal stromal cells, highlighting the impact of this field on patient care. Copyright 2019 The Author(s).
    Keyword
    Biotechnology
    Cell therapy
    Immunotherapy
    Mesenchymal stromal cells
    Regenerative medicine
    Stem cells
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062416900&doi=10.1186%2fs12916-019-1289-6&partnerID=40&md5=8844b451a409e903cbad516c903ee028; http://hdl.handle.net/10713/10166
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12916-019-1289-6
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