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    A promiscuous kinase inhibitor reveals secrets to cancer cell survival

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    Author
    Shapiro, P.
    Date
    2019
    Journal
    Journal of Biological Chemistry
    Publisher
    American Society for Biochemistry and Molecular Biology Inc.
    Type
    article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1074/jbc.H119.009103
    Abstract
    Deregulated kinase signaling networks drive the growth and survival of many cancer cells. However, the genetic complexity and rapidly evolving nature of most cancer cells create challenges when identifying the most relevant kinases to inhibit to achieve optimal therapeutic benefits. A new strategy that takes advantage of a well-characterized multitargeted kinase inhibitor describes a nongenetic approach to tease out key kinases that promote proliferation of specific cancer cell types. Copyright 2019 Shapiro.
    Keyword
    Molecular Targeted Therapy
    Neoplasms--prevention & control
    Protein Kinase Inhibitors
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066943033&doi=10.1074%2fjbc.H119.009103&partnerID=40&md5=9e52f0e53f6ddfae7644b88ef19f9501; http://hdl.handle.net/10713/10157
    ae974a485f413a2113503eed53cd6c53
    10.1074/jbc.H119.009103
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