A promiscuous kinase inhibitor reveals secrets to cancer cell survival
JournalJournal of Biological Chemistry
PublisherAmerican Society for Biochemistry and Molecular Biology Inc.
MetadataShow full item record
AbstractDeregulated kinase signaling networks drive the growth and survival of many cancer cells. However, the genetic complexity and rapidly evolving nature of most cancer cells create challenges when identifying the most relevant kinases to inhibit to achieve optimal therapeutic benefits. A new strategy that takes advantage of a well-characterized multitargeted kinase inhibitor describes a nongenetic approach to tease out key kinases that promote proliferation of specific cancer cell types. Copyright 2019 Shapiro.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85066943033&doi=10.1074%2fjbc.H119.009103&partnerID=40&md5=9e52f0e53f6ddfae7644b88ef19f9501; http://hdl.handle.net/10713/10157