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    Imaging stem cell distribution, growth, migration, and differentiation in 3-D scaffolds for bone tissue engineering using mesoscopic fluorescence tomography

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    Author
    Tang, Q.
    Piard, C.
    Lin, J.
    Date
    2018
    Journal
    Biotechnology and Bioengineering
    Publisher
    John Wiley and Sons Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.1002/bit.26452
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699959/
    Abstract
    Regenerative medicine has emerged as an important discipline that aims to repair injury or replace damaged tissues or organs by introducing living cells or functioning tissues. Successful regenerative medicine strategies will likely depend upon a simultaneous optimization strategy for the design of biomaterials, cell-seeding methods, cell-biomaterial interactions and molecular signaling within the engineered tissues. It remains a challenge to image three-dimensional (3-D) structures and functions of the cell-seeded scaffold in mesoscopic scale (>2~3 mm). In this study, we utilized angled fluorescence laminar optical tomography (aFLOT), which allows depth-resolved molecular characterization of engineered tissues in 3-D to investigate cell viability, migration and bone mineralization within bone tissue engineering scaffolds in situ. Copyright 2017 Wiley Periodicals, Inc.
    Sponsors
    National Institutes of Health, Grant number: R01 EB014946
    Keyword
    3-D cell printing
    bone mineralization
    bone tissue scaffold
    cell migration
    mesoscopic fluorescence tomography
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85035057526&doi=10.1002%2fbit.26452&partnerID=40&md5=e2f46d5761403441fabab98e71e6c197; http://hdl.handle.net/10713/10148
    ae974a485f413a2113503eed53cd6c53
    10.1002/bit.26452
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    UMB Open Access Articles 2018

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