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    Vaccines Against Shigella and Enterotoxigenic Escherichia coli: A summary of the 2018 VASE Conference

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    Author
    Barry, Eileen
    Cassels, Fred
    Riddle, Mark
    Date
    2019-08-07
    Journal
    Vaccine
    Publisher
    Elsevier Ltd.
    Type
    Article
    
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    See at
    https://doi.org/10.1016/j.vaccine.2019.02.070
    Abstract
    PATH hosted the second Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference in Mexico City in June 2018, again providing experts from around the world an opportunity to participate in a highly collaborative forum to discuss progress in the development of new enteric vaccines. Through a combination of plenary sessions and posters, keynote presentations, and workshops, the 2018 VASE Conference aimed to accelerate communication and progress among those working to achieve the goal of licensed vaccines against these two bacterial pathogens. Many presentations recognized the importance of diarrheal disease and long-term sequelae caused by infections with Shigella and enterotoxigenic E. coli (ETEC). Other presentations explored new strategies for vaccine development, including the search for novel, possibly conserved, antigens for more effective vaccines. Much progress is being made as some vaccine candidates are now moving through clinical trials. Research presented in oral and poster presentations at the VASE Conference covered a range of topics, including: the global burden of disease, epidemiology, and health economics; host parameters and genomics that predict responses to infection and disease; preclinical evaluations of vaccine antigens and models of enteric diseases; and vaccine candidates in clinical trials and human challenge studies. This article reviews key points and highlighted research presented in each of the plenary conference sessions and poster presentations at the 2018 VASE Conference. © 2019 The Authors
    Keyword
    Diarrhea
    ETEC
    Immunization
    Shigella
    Stunting
    Vaccines
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063382460&origin=inward; http://hdl.handle.net/10713/10144
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.vaccine.2019.02.070
    Scopus Count
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    UMB Open Access Articles 2019

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