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    Brain gray matter alterations in Chinese patients with chronic knee osteoarthritis pain based on voxel-based morphometry

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    Author
    Liao, Xia
    Mao, Cuiping
    Seminowicz, David A.
    Date
    2018-03-01
    Journal
    Medicine (United States)
    Publisher
    Lippincott Williams and Wilkins
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1097/MD.0000000000010145
    Abstract
    Altered cerebral gray matter volume (GMV) is commonly found in patients with chronic pain. Chronic pain is the prominent characteristic of knee osteoarthritis (KOA), yet little is known about its morphological changes in the brain. Here an MRI study was performed to examine the structural brain abnormalities in 30 KOA patients with knee pain and age-matched healthy subjects. We detected that the patients exhibited significant almost 2-fold age-related decreases of GMV compared to healthy controls. Moreover, KOA patients also had significant loss of regional GMV including in the bilateral orbital frontal cortex (OFC), the right lateral prefrontal cortex (lPFC), and precentral and postcentral cortices. In addition, a high proportion of KOA patients exerted abnormal scores of Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale (HAMA), Mini Mental State examination (MMSE), and Montreal Cognitive Assessment (MoCA) compare to controls. Our results imply that chronic pain conditions which preferentially involve PFC might consider as a "cognitive state." And emotion and cognitive function about chronic pain should be highly regarded. Copyright © 2018 the Author(s).
    Keyword
    chronic pain
    gray matter
    knee osteoarthritis
    magnetic resonance imaging
    voxel-based morphometry
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045137317&origin=inward; http://hdl.handle.net/10713/10134
    ae974a485f413a2113503eed53cd6c53
    10.1097/MD.0000000000010145
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