AuthorKrimmel, Samuel R.
White, Michael G.
Mathur, Brian N.
Seminowicz, David A.
JournalFrontiers in Neuroanatomy
PublisherFrontiers Media S.A.
MetadataShow full item record
AbstractThe claustrum is structurally connected with many cortical areas.A major hurdle standing in the way of understanding claustrum function is the difficulty in assessing the global functional connectivity (FC) of this structure. The primary issues lie in the inability to isolate claustrum signal from the adjacent insular cortex (Ins), caudate/putamen (CPu), and endopiriform nucleus (Endo). To address this issue, we used (7T) fMRI in the rat and describe a novel analytic method to study claustrum without signal contamination from the surrounding structures. Using this approach, we acquired claustrum signal distinct from Ins, CPu, and Endo, and used this claustrum signal to determine whole brain resting state functional connectivity (RSFC). Claustrum RSFC was distinct from the adjacent structures and displayed extensive connections with sensory cortices and the cingulate cortex, consistent with known structural connectivity of the claustrum. These results suggest fMRI and improved analysis can be combined to accurately assay claustrum function. © 2019 The Authors
SponsorsThis work was supported by National Institute on Alcohol Abuse and Alcoholism grants K22AA021414, R01AA024845 (BM), Whitehall Foundation grant 2014-12-68 (BM), National Institute of General Medical Sciences grant T32008181 (MW), National Institute of Neurological Disorders and Stroke grant T32NS063391 (MW), and National Center for Complementary and Integrative Health grant R01AT007176 (DS). DR was supported by NHMRC Project Grant APP1068140.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064116273&origin=inward; http://hdl.handle.net/10713/10133