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    Resting state functional connectivity of the rat claustrum

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    Author
    Krimmel, Samuel R.
    Qadir, Houman
    Hesselgrave, Natalie
    White, Michael G.
    Mathur, Brian N.
    Seminowicz, David A.
    Date
    2019-02-18
    Journal
    Frontiers in Neuroanatomy
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
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    See at
    https://doi.org/10.3389/fnana.2019.00022
    Abstract
    The claustrum is structurally connected with many cortical areas.A major hurdle standing in the way of understanding claustrum function is the difficulty in assessing the global functional connectivity (FC) of this structure. The primary issues lie in the inability to isolate claustrum signal from the adjacent insular cortex (Ins), caudate/putamen (CPu), and endopiriform nucleus (Endo). To address this issue, we used (7T) fMRI in the rat and describe a novel analytic method to study claustrum without signal contamination from the surrounding structures. Using this approach, we acquired claustrum signal distinct from Ins, CPu, and Endo, and used this claustrum signal to determine whole brain resting state functional connectivity (RSFC). Claustrum RSFC was distinct from the adjacent structures and displayed extensive connections with sensory cortices and the cingulate cortex, consistent with known structural connectivity of the claustrum. These results suggest fMRI and improved analysis can be combined to accurately assay claustrum function. © 2019 The Authors
    Sponsors
    This work was supported by National Institute on Alcohol Abuse and Alcoholism grants K22AA021414, R01AA024845 (BM), Whitehall Foundation grant 2014-12-68 (BM), National Institute of General Medical Sciences grant T32008181 (MW), National Institute of Neurological Disorders and Stroke grant T32NS063391 (MW), and National Center for Complementary and Integrative Health grant R01AT007176 (DS). DR was supported by NHMRC Project Grant APP1068140.
    Keyword
    Anterior cingulate cortex
    Caudate
    Cortex
    Forebrain
    Insula
    Putamen
    Striatum
    Top-down
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064116273&origin=inward; http://hdl.handle.net/10713/10133
    ae974a485f413a2113503eed53cd6c53
    10.3389/fnana.2019.00022
    Scopus Count
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