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    Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women

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    Author
    Jung, S.
    Allen, N.
    Arslan, A.A.
    Date
    2017
    Journal
    Fertility and Sterility
    Publisher
    Elsevier Inc.
    Type
    Article
    
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    https://www.doi.org/10.1016/j.fertnstert.2017.02.105
    Abstract
    Objective: To identify reproductive, lifestyle, hormonal, and other correlates of circulating antimüllerian hormone (AMH) concentrations in mostly late premenopausal women. Design: Cross-sectional study. Setting: Not applicable. Patient(s): A total of 671 premenopausal women not known to have cancer. Intervention(s): None. Main Outcome Measure(s): Concentrations of AMH were measured in a single laboratory using the picoAMH ELISA. Multivariable-adjusted median (and interquartile range) AMH concentrations were calculated using quantile regression for several potential correlates. Result(s): Older women had significantly lower AMH concentrations (≥40 [n = 444] vs. <35 years [n = 64], multivariable-adjusted median 0.73 ng/mL vs. 2.52 ng/mL). Concentrations of AMH were also significantly lower among women with earlier age at menarche (<12 [n = 96] vs. ≥14 years [n = 200]: 0.90 ng/mL vs. 1.12 ng/mL) and among current users of oral contraceptives (n = 27) compared with never or former users (n = 468) (0.36 ng/mL vs. 1.15 ng/mL). Race, body mass index, education, height, smoking status, parity, and menstrual cycle phase were not significantly associated with AMH concentrations. There were no significant associations between AMH concentrations and androgen or sex hormone-binding globulin concentrations or with factors related to blood collection (e.g., sample type, time, season, and year of blood collection). Conclusion(s): Among premenopausal women, lower AMH concentrations are associated with older age, a younger age at menarche, and currently using oral contraceptives, suggesting these factors are related to a lower number or decreased secretory activity of ovarian follicles. Copyright 2017 American Society for Reproductive Medicine
    Keyword
    Antimüllerian hormone
    demographic
    lifestyle
    ovarian reserve
    reproductive factors
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016464932&doi=10.1016%2fj.fertnstert.2017.02.105&partnerID=40&md5=9dc12ca96d8927496d5d5b2bca1800a1; http://hdl.handle.net/10713/10128
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.fertnstert.2017.02.105
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    UMB Open Access Articles 2017

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