A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies
Date
2019-03-20Journal
Human Vaccines and ImmunotherapeuticsPublisher
Taylor and Francis Inc.Type
Article
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Enterotoxigenic Escherichia coli (ETEC) is a major cause of travelers’ diarrhea and of diarrhea among young children in developing countries. Experimental challenge studies in adult volunteers have played a pivotal role in establishing ETEC as an enteric pathogen, elucidating its pathogenesis by identifying specific virulence attributes, characterizing the human immune response to clinical and sub-clinical ETEC infection and assessing preliminarily the clinical acceptability, immunogenicity and efficacy of prototype ETEC vaccines. This review provides a historical perspective of experimental challenge studies with ETEC. It summarizes pioneering early studies carried out by investigators at the University of Maryland School of Medicine to show how those studies provided key information that influenced the directions taken by many research groups to develop vaccines to prevent ETEC. In addition, key experimental challenge studies undertaken at other institutions will also be cited. © 2019 The Author(s).Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068893813&origin=inward; http://hdl.handle.net/10713/10118ae974a485f413a2113503eed53cd6c53
10.1080/21645515.2019.1578922
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