• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Levine, Myron M.
    Barry, Eileen M.
    Chen, Wilbur H.
    Date
    2019-03-20
    Journal
    Human Vaccines and Immunotherapeutics
    Publisher
    Taylor and Francis Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.1080/21645515.2019.1578922
    Abstract
    Enterotoxigenic Escherichia coli (ETEC) is a major cause of travelers’ diarrhea and of diarrhea among young children in developing countries. Experimental challenge studies in adult volunteers have played a pivotal role in establishing ETEC as an enteric pathogen, elucidating its pathogenesis by identifying specific virulence attributes, characterizing the human immune response to clinical and sub-clinical ETEC infection and assessing preliminarily the clinical acceptability, immunogenicity and efficacy of prototype ETEC vaccines. This review provides a historical perspective of experimental challenge studies with ETEC. It summarizes pioneering early studies carried out by investigators at the University of Maryland School of Medicine to show how those studies provided key information that influenced the directions taken by many research groups to develop vaccines to prevent ETEC. In addition, key experimental challenge studies undertaken at other institutions will also be cited. © 2019 The Author(s).
    Keyword
    enteric pathogen
    epidemiology
    ETEC
    travelers diarrhea
    Vaccines
    vaccinology
    volunteer challenge
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068893813&origin=inward; http://hdl.handle.net/10713/10118
    ae974a485f413a2113503eed53cd6c53
    10.1080/21645515.2019.1578922
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Preclinical Characterization of Immunogenicity and Efficacy against Diarrhea from MecVax, a Multivalent Enterotoxigenic E. coli Vaccine Candidate.
    • Authors: Seo H, Garcia C, Ruan X, Duan Q, Sack DA, Zhang W
    • Issue date: 2021 Jun 16
    • Enterotoxigenic Escherichia coli Adhesin-Toxoid Multiepitope Fusion Antigen CFA/I/II/IV-3xSTa(N12S)-mnLT(G192G/L211A)-Derived Antibodies Inhibit Adherence of Seven Adhesins, Neutralize Enterotoxicity of LT and STa Toxins, and Protect Piglets against Diarrhea.
    • Authors: Nandre R, Ruan X, Lu T, Duan Q, Sack D, Zhang W
    • Issue date: 2018 Mar
    • Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge.
    • Authors: Harro C, Louis Bourgeois A, Sack D, Walker R, DeNearing B, Brubaker J, Maier N, Fix A, Dally L, Chakraborty S, Clements JD, Saunders I, Darsley MJ
    • Issue date: 2019 Mar 28
    • Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTa(N12S)-dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model.
    • Authors: Nandre RM, Duan Q, Wang Y, Zhang W
    • Issue date: 2017 Jan 23
    • Characterization of Mucosal Immune Responses to Enterotoxigenic Escherichia coli Vaccine Antigens in a Human Challenge Model: Response Profiles after Primary Infection and Homologous Rechallenge with Strain H10407.
    • Authors: Chakraborty S, Harro C, DeNearing B, Ram M, Feller A, Cage A, Bauers N, Bourgeois AL, Walker R, Sack DA
    • Issue date: 2016 Jan
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.