Antibodies to peptides in semiconserved domains of RIFINs and STEVORs correlate with malaria exposure
AuthorBerry, Andrea A.
Stucke, Emily M.
Lyke, Kirsten E.
Travassos, Mark A.
Ouattara, Amed T.
Zhou, Albert E.
PublisherAmerican Society for Microbiology
MetadataShow full item record
AbstractThe repetitive interspersed family (RIFIN) and the subtelomeric variable open reading frame (STEVOR) family represent two of three major Plasmodium falciparum variant surface antigen families involved in malaria pathogenesis and immune evasion and are potential targets in the development of natural immunity. Protein and peptide microarrays populated with RIFINs and STEVORs associated with severe malaria vulnerability in Malian children were probed with adult and pediatric sera to identify epitopes that reflect malaria exposure. Adult sera recognized and reacted with greater intensity to all STEVOR proteins than pediatric sera did. Serorecognition of and seroreactivity to peptides within the semiconserved domain of STEVORs increased with age and seasonal malaria exposure, while serorecognition and seroreactivity increased for the semiconserved and second hypervariable domains of RIFINs only with age. Serologic responses to RIFIN and STEVOR peptides within the semiconserved domains may play a role in natural immunity to severe malaria.
SponsorsThis work was supported by a cooperative agreement (U19AI065683) from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S., and by National Institutes of Health contract N01-AI-85346 and grants R01HL130750, R01AI099628, and R01AI093635; by a training grant (D43TW001589) from the Fogarty International Center of the National Institutes of Health; and by awards to C. V. Plowe from the Doris Duke Charitable Foundation and the Howard Hughes Medical Institute.
Variant surface antigen
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063611867&origin=inward; http://hdl.handle.net/10713/10081