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dc.contributor.authorTostanoski, L.H.
dc.contributor.authorJewell, C.M.
dc.date.accessioned2019-07-15T16:17:01Z
dc.date.available2019-07-15T16:17:01Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85017430623&doi=10.1016%2fj.addr.2017.03.005&partnerID=40&md5=845a6376c51fb51dbbbac49360a207e5
dc.identifier.urihttp://hdl.handle.net/10713/10061
dc.description.abstractThe immune system is an awe-inspiring control structure that maintains a delicate and constantly changing balance between pro-immune functions that fight infection and cancer, regulatory or suppressive functions involved in immune tolerance, and homeostatic resting states. These activities are determined by integrating signals in space and time; thus, improving control over the densities, combinations, and durations with which immune signals are delivered is a central goal to better combat infectious disease, cancer, and autoimmunity. Self-assembly presents a unique opportunity to synthesize materials with well-defined compositions and controlled physical arrangement of molecular building blocks. This review highlights strategies exploiting these capabilities to improve the understanding of how precisely-displayed cues interact with immune cells and tissues. We present work centered on fundamental properties that regulate the nature and magnitude of immune response, highlight pre-clinical and clinical applications of self-assembled technologies in vaccines, cancer, and autoimmunity, and describe some of the key manufacturing and regulatory hurdles facing these areas. Copyright 2017 The Authorsen_US
dc.description.sponsorshipThis work was supported in part by the National Multiple Sclerosis Society Award # RG-1501-02968, the Damon Runyon Foundation # DRR3415, NSF CAREER Award # 1351688, Alex's Lemonade Stand # 27120, and the Juvenile Diabetes Research Foundation # 2-SRA-2016-319-S-B. L.H.T. is an NSF Graduate Fellow (# DGE1322106).en_US
dc.description.urihttps://www.doi.org/10.1016/j.addr.2017.03.005en_US
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofAdvanced Drug Delivery Reviews
dc.subjectAutoimmunity and toleranceen_US
dc.subjectBiomaterialen_US
dc.subjectCanceren_US
dc.subjectImmunomodulationen_US
dc.subjectManufacturing, regulatory approval and FDAen_US
dc.subjectNanoparticle, microparticle, micelle, liposome, polyplex, lipoplex, polyelectrolyte multilayeren_US
dc.subjectNanotechnologyen_US
dc.subjectNon-covalent, hydrophobic, hydrogen bonding, and electrostatic interactionen_US
dc.subjectSelf-assemblyen_US
dc.subjectSensor, diagnostic, and theranosticen_US
dc.subjectVaccine and immunotherapyen_US
dc.titleEngineering self-assembled materials to study and direct immune functionen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.addr.2017.03.005
dc.identifier.pmid28392305


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