• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2017
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2017
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Engineering self-assembled materials to study and direct immune function

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Author
    Tostanoski, L.H.
    Jewell, C.M.
    Date
    2017
    Journal
    Advanced Drug Delivery Reviews
    Publisher
    Elsevier B.V.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.1016/j.addr.2017.03.005
    Abstract
    The immune system is an awe-inspiring control structure that maintains a delicate and constantly changing balance between pro-immune functions that fight infection and cancer, regulatory or suppressive functions involved in immune tolerance, and homeostatic resting states. These activities are determined by integrating signals in space and time; thus, improving control over the densities, combinations, and durations with which immune signals are delivered is a central goal to better combat infectious disease, cancer, and autoimmunity. Self-assembly presents a unique opportunity to synthesize materials with well-defined compositions and controlled physical arrangement of molecular building blocks. This review highlights strategies exploiting these capabilities to improve the understanding of how precisely-displayed cues interact with immune cells and tissues. We present work centered on fundamental properties that regulate the nature and magnitude of immune response, highlight pre-clinical and clinical applications of self-assembled technologies in vaccines, cancer, and autoimmunity, and describe some of the key manufacturing and regulatory hurdles facing these areas. Copyright 2017 The Authors
    Sponsors
    This work was supported in part by the National Multiple Sclerosis Society Award # RG-1501-02968, the Damon Runyon Foundation # DRR3415, NSF CAREER Award # 1351688, Alex's Lemonade Stand # 27120, and the Juvenile Diabetes Research Foundation # 2-SRA-2016-319-S-B. L.H.T. is an NSF Graduate Fellow (# DGE1322106).
    Keyword
    Autoimmunity and tolerance
    Biomaterial
    Cancer
    Immunomodulation
    Manufacturing, regulatory approval and FDA
    Nanoparticle, microparticle, micelle, liposome, polyplex, lipoplex, polyelectrolyte multilayer
    Nanotechnology
    Non-covalent, hydrophobic, hydrogen bonding, and electrostatic interaction
    Self-assembly
    Sensor, diagnostic, and theranostic
    Vaccine and immunotherapy
    Show allShow less
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017430623&doi=10.1016%2fj.addr.2017.03.005&partnerID=40&md5=845a6376c51fb51dbbbac49360a207e5; http://hdl.handle.net/10713/10061
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.addr.2017.03.005
    Scopus Count
    Collections
    UMB Open Access Articles 2017

    entitlement

    Related articles

    • Improving Vaccine and Immunotherapy Design Using Biomaterials.
    • Authors: Bookstaver ML, Tsai SJ, Bromberg JS, Jewell CM
    • Issue date: 2018 Feb
    • Biomaterials as Tools to Decode Immunity.
    • Authors: Eppler HB, Jewell CM
    • Issue date: 2020 Apr
    • Engineering Immune Tolerance with Biomaterials.
    • Authors: Gammon JM, Jewell CM
    • Issue date: 2019 Feb
    • Engineering vaccines and niches for immune modulation.
    • Authors: Purwada A, Roy K, Singh A
    • Issue date: 2014 Apr
    • Harnessing the layer-by-layer assembly technique to design biomaterials vaccines for immune modulation in translational applications.
    • Authors: Tang T, Weng T, Jia H, Luo S, Xu Y, Li L, Zhang P
    • Issue date: 2019 Feb 26
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.