Engineering self-assembled materials to study and direct immune function
JournalAdvanced Drug Delivery Reviews
MetadataShow full item record
AbstractThe immune system is an awe-inspiring control structure that maintains a delicate and constantly changing balance between pro-immune functions that fight infection and cancer, regulatory or suppressive functions involved in immune tolerance, and homeostatic resting states. These activities are determined by integrating signals in space and time; thus, improving control over the densities, combinations, and durations with which immune signals are delivered is a central goal to better combat infectious disease, cancer, and autoimmunity. Self-assembly presents a unique opportunity to synthesize materials with well-defined compositions and controlled physical arrangement of molecular building blocks. This review highlights strategies exploiting these capabilities to improve the understanding of how precisely-displayed cues interact with immune cells and tissues. We present work centered on fundamental properties that regulate the nature and magnitude of immune response, highlight pre-clinical and clinical applications of self-assembled technologies in vaccines, cancer, and autoimmunity, and describe some of the key manufacturing and regulatory hurdles facing these areas. Copyright 2017 The Authors
SponsorsThis work was supported in part by the National Multiple Sclerosis Society Award # RG-1501-02968, the Damon Runyon Foundation # DRR3415, NSF CAREER Award # 1351688, Alex's Lemonade Stand # 27120, and the Juvenile Diabetes Research Foundation # 2-SRA-2016-319-S-B. L.H.T. is an NSF Graduate Fellow (# DGE1322106).
KeywordAutoimmunity and tolerance
Manufacturing, regulatory approval and FDA
Nanoparticle, microparticle, micelle, liposome, polyplex, lipoplex, polyelectrolyte multilayer
Non-covalent, hydrophobic, hydrogen bonding, and electrostatic interaction
Sensor, diagnostic, and theranostic
Vaccine and immunotherapy
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85017430623&doi=10.1016%2fj.addr.2017.03.005&partnerID=40&md5=845a6376c51fb51dbbbac49360a207e5; http://hdl.handle.net/10713/10061
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