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dc.contributor.authorRemy, K.E.
dc.contributor.authorCuster, J.W.
dc.contributor.authorCappell, J.
dc.date.accessioned2019-07-15T16:17:01Z
dc.date.available2019-07-15T16:17:01Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85041954928&doi=10.3389%2ffped.2017.00250&partnerID=40&md5=b55b3ea987d1478d0ad594ae77c9bfc5
dc.identifier.urihttp://hdl.handle.net/10713/10060
dc.description.abstractPurpose: Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is being recognized with increasing frequency among children. Given the paucity of evidence to guide the critical care management of these complex patients, we provide a comprehensive review of the literature with pooled analysis of published case reports and case series. Methods: We performed a comprehensive literature search using PubMed, Scopus, EMBASE, and Web of Science for relevant published studies. The literature search was conducted using the terms NMDA, anti-NMDA, Anti-N-methyl-d-aspartate, pediatric encephalitis, and anti-NMDAR and included articles published between 2005 and May 1, 2016. Results: Forty-eight references met inclusion criteria accounting for 373 cases. For first-line treatments, 335 (89.8%) received high-dose corticosteroids, 296 received intravenous immunoglobulin (79.3%), and 116 (31%) received therapeutic plasma exchange. In these, 187 children (50.1%) had a full recovery with only minor deficits, 174 patients (46.7%) had partial recovery with major deficits, and 12 children died. In addition, 14 patients were reported to require mechanical ventilation. Conclusion: Anti-NMDA encephalitis is a formidable disease with great variation in clinical presentation and response to treatment. With early recognition of this second most common cause of pediatric encephalitis, a multidisciplinary approach by physicians may provide earlier access to first- and second-line therapies. Future studies are needed to examine the efficacy of these current therapeutic strategies on long-term morbidity. Copyright 2017 Remy, Custer, Cappell, Foster, Garber, Walker, Simon and Bagdure.en_US
dc.description.urihttps://www.doi.org/10.3389/fped.2017.00250en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Pediatrics
dc.subjectAutoimmuneen_US
dc.subjectCritical careen_US
dc.subjectEncephalitisen_US
dc.subjectN-methyl-d-aspartateen_US
dc.subjectN-methyl-d-aspartate receptoren_US
dc.subjectParaneoplasticen_US
dc.subjectPediatricsen_US
dc.titlePediatric anti-N-methyl-d-aspartate receptor encephalitis: A review with pooled analysis and critical care emphasisen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fped.2017.00250


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