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    Distinct Translaminar Glutamatergic Circuits to GABAergic Interneurons in the Neonatal Auditory Cortex

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    Author
    Deng, R.
    Kao, J.P.Y.
    Kanold, P.O.
    Date
    2017
    Journal
    Cell Reports
    Publisher
    Elsevier B.V.
    Type
    Article
    
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    See at
    https://www.doi.org/10.1016/j.celrep.2017.04.044
    Abstract
    GABAergic activity is important in neocortical development and plasticity. Because the maturation of GABAergic interneurons is regulated by neural activity, the source of excitatory inputs to GABAergic interneurons plays a key role in development. We show, by laser-scanning photostimulation, that layer 4 and layer 5 GABAergic interneurons in the auditory cortex in neonatal mice (<P7) receive extensive translaminar glutamatergic input via NMDAR-only synapses. Extensive translaminar AMPAR-mediated input developed during the second postnatal week, whereas NMDAR-only presynaptic connections decreased. GABAergic interneurons showed two spatial patterns of translaminar connection: inputs originating predominantly from supragranular or from supragranular and infragranular layers, including the subplate, which relays early thalamocortical activity. Sensory deprivation altered the development of translaminar inputs. Thus, distinct translaminar circuits to GABAergic interneurons exist throughout development, and the maturation of excitatory synapses is input-specific. Glutamatergic signaling from subplate and intracortical sources likely plays a role in the maturation of GABAergic interneurons. Copyright 2017 The Author(s)
    Sponsors
    This work was supported by NIH RO1DC009607 (to P.O.K.) and NIH R01GM056481 (to J.P.Y.K.).
    Keyword
    auditory cortex
    development
    GABA
    interneuron
    NMDA
    silent synapse
    subplate
    translaminar
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019215279&doi=10.1016%2fj.celrep.2017.04.044&partnerID=40&md5=ec0935005de565585aed7cd2987e81f0; http://hdl.handle.net/10713/10056
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.celrep.2017.04.044
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    UMB Open Access Articles 2017

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