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dc.contributor.authorMeng, X.
dc.contributor.authorKao, J.P.Y.
dc.contributor.authorLee, H.-K.
dc.date.accessioned2019-07-15T16:17:01Z
dc.date.available2019-07-15T16:17:01Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85032144391&doi=10.1523%2fENEURO.0092-17.2017&partnerID=40&md5=0da59f333f10ca56c217d3aec93140da
dc.identifier.urihttp://hdl.handle.net/10713/10055
dc.description.abstractSensory cortices do not work in isolation. The functional responses of neurons in primary sensory cortices can be affected by activity from other modalities. For example, short-term visual deprivations, or dark exposure (DE), leads to enhanced neuronal responses and frequency selectivity to sounds in layer 4 (L4) of primary auditory cortex (A1). Circuit changes within A1 likely underlie these changes. Prior studies revealed that DE enhanced thalamocortical transmission to L4 in A1. Because the frequency selectivity of L4 neurons is determined by both thalamocortical and intracortical inputs, changes in intralaminar circuits to L4 neurons might also contribute to improved sound responses. We thus investigated in mouse A1 whether intracor- tical circuits to L4 cells changed after DE. Using in vitro whole-cell patch recordings in thalamocortical slices from mouse auditory cortex, we show that DE can lead to refinement of interlaminar excitatory as well as inhibitory connections from L2/3 to L4 cells, manifested as a weakening of these connections. The circuit refinement is present along the tonotopic axis, indicating reduced integration along the tonotopic axis. Thus, cross-modal influences may alter the spectral and temporal processing of sensory stimuli in multiple cortical layers by refinement of thalamocortical and intracortical circuits. Copyright 2017 Meng et al.en_US
dc.description.sponsorshipSupported by NIH R01EY022720 (HKL and POK) and NIH R01 GM056481 (JPYK).en_US
dc.description.urihttps://www.doi.org/10.1523/ENEURO.0092-17.2017en_US
dc.language.isoen_USen_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.ispartofeNeuro
dc.subjectAuditory cortexen_US
dc.subjectCrossmodalen_US
dc.subjectDark exposureen_US
dc.subjectIntracorticalen_US
dc.subjectMouseen_US
dc.subjectRefinementen_US
dc.subjectVisual deprivationen_US
dc.titleIntracortical circuits in thalamorecipient layers of auditory cortex refine after visual deprivationen_US
dc.typeArticleen_US
dc.identifier.doi10.1523/ENEURO.0092-17.2017
dc.identifier.pmid28396883


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