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dc.contributor.authorNguyen, K.T.
dc.contributor.authorVittinghoff, E.
dc.contributor.authorDewland, T.A.
dc.date.accessioned2019-07-15T16:17:00Z
dc.date.available2019-07-15T16:17:00Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85030694207&doi=10.1161%2fJAHA.117.006028&partnerID=40&md5=1e17b9cd4479f8f1599f757761c06dc2
dc.identifier.urihttp://hdl.handle.net/10713/10051
dc.description.abstractBackground--Atrial fibrillation and heart failure are 2 of the most common diseases, yet ready means to identify individuals at risk are lacking. The 12-lead ECG is one of the most accessible tests in medicine. Our objective was to determine whether a premature atrial contraction observed on a standard 12-lead ECG would predict atrial fibrillation and mortality and whether a premature ventricular contraction would predict heart failure and mortality. Methods and Results--We utilized the CHS (Cardiovascular Health) Study, which followed 5577 participants for a median of 12 years, as the primary cohort. The ARIC (Atherosclerosis Risk in Communities Study), the replication cohort, captured data from 15 792 participants over a median of 22 years. In the CHS, multivariable analyses revealed that a baseline 12-lead ECG premature atrial contraction predicted a 60% increased risk of atrial fibrillation (hazard ratio, 1.6; 95% CI, 1.3-2.0; P < 0.001) and a premature ventricular contraction predicted a 30% increased risk of heart failure (hazard ratio, 1.3; 95% CI, 1.0-1.6; P=0.021). In the negative control analyses, neither predicted incident myocardial infarction. A premature atrial contraction was associated with a 30% increased risk of death (hazard ratio, 1.3; 95% CI, 1.1-1.5; P=0.008) and a premature ventricular contraction was associated with a 20% increased risk of death (hazard ratio, 1.2; 95% CI, 1.0-1.3; P=0.044). Similarly statistically significant results for each analysis were also observed in ARIC. Conclusions--Based on a single standard ECG, a premature atrial contraction predicted incident atrial fibrillation and death and a premature ventricular contraction predicted incident heart failure and death, suggesting that this commonly used test may predict future disease. Copyright 2017 The Authors and Medtronic.en_US
dc.description.sponsorshipThis work was made possible by the Joseph Drown Foundation (Marcus), R25MD00683, the National Institute on Minority Health and Health Disparities (Nguyen), and grant 16EIA26410001 from the American Heart Association (Alonso). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Grants and contracts for the Cardiovascular Health Study include: contracts HHSN268201200036C, HHSN268200800007C, N01HC 55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086.en_US
dc.description.urihttps://www.doi.org/10.1161/JAHA.117.006028en_US
dc.language.isoen_USen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofJournal of the American Heart Association
dc.subjectAtrial fibrillationen_US
dc.subjectHeart failureen_US
dc.subjectMortalityen_US
dc.subjectPremature atrial contractionsen_US
dc.subjectPremature ventricular contractionsen_US
dc.titleEctopy on a Single 12-Lead ECG, Incident Cardiac Myopathy, and Death in the Communityen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/JAHA.117.006028
dc.identifier.pmid28775064


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