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dc.contributor.authorYahagi, K.
dc.contributor.authorKolodgie, F.D.
dc.contributor.authorLutter, C.
dc.date.accessioned2019-07-15T16:17:00Z
dc.date.available2019-07-15T16:17:00Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85002168805&doi=10.1161%2fATVBAHA.116.306256&partnerID=40&md5=0a3cfb2146f81a89056e134ae8731d31
dc.identifier.urihttp://hdl.handle.net/10713/10047
dc.description.abstractThe continuing increase in the prevalence of diabetes mellitus in the general population is predicted to result in a higher incidence of cardiovascular disease. Although the mechanisms of diabetes mellitus-associated progression of atherosclerosis are not fully understood, at clinical and pathological levels, there is an appreciation of increased disease burden and higher levels of arterial calcification in these subjects. Plaques within the coronary arteries of patients with diabetes mellitus generally exhibit larger necrotic cores and significantly greater inflammation consisting mainly of macrophages and T lymphocytes relative to patients without diabetes mellitus. Moreover, there is a higher incidence of healed plaque ruptures and positive remodeling in hearts from subjects with type 1 diabetes mellitus and type 2 diabetes mellitus, suggesting a more active atherogenic process. Lesion calcification in the coronary, carotid, and other arterial beds is also more extensive. Although the role of coronary artery calcification in identifying cardiovascular disease and predicting its outcome is undeniable, our understanding of how key hormonal and physiological alterations associated with diabetes mellitus such as insulin resistance and hyperglycemia influence the process of vascular calcification continues to grow. Important drivers of atherosclerotic calcification in diabetes mellitus include oxidative stress, endothelial dysfunction, alterations in mineral metabolism, increased inflammatory cytokine production, and release of osteoprogenitor cells from the marrow into the circulation. Our review will focus on the pathophysiology of type 1 diabetes mellitus- and type 2 diabetes mellitus-associated vascular disease with particular focus on coronary and carotid atherosclerotic calcification. Copyright 2016 American Heart Association, Inc.en_US
dc.description.urihttps://www.doi.org/10.1161/ATVBAHA.116.306256en_US
dc.language.isoen_USen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofArteriosclerosis, Thrombosis, and Vascular Biology
dc.subjectatherosclerosisen_US
dc.subjectcarotid arteriesen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectdeath, suddenen_US
dc.subjectdiabetes mellitusen_US
dc.titlePathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitusen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/ATVBAHA.116.306256
dc.identifier.pmid27908890


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