PublisherBlackwell Publishing Inc.
MetadataShow full item record
AbstractPresentation of sialic acid (Sia) varies among different tissues and organs within each species, and between species. This diversity has biologically important consequences regarding the recognition of cells by "xeno" antibodies (Neu5Gc vs Neu5Ac). Sia also plays a central role in inflammation by influencing binding of the asialoglycoprotein receptor 1 (ASGR-1), Siglec-1 (Sialoadhesin), and cellular interactions mediated by the selectin, integrin, and galectin receptor families. This review will focus on what is known about basic Sia structure and function in association with xenotransplantation, how changes in sialylation may occur in this context (through desialylation or changes in sialyltransferases), and how this fundamental pathway modulates adhesive and cell activation pathways that appear to be particularly crucial to homeostasis and inflammation for xenografts. Copyright 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
SponsorsThese studies were supported by U19 AI090959, P01 HL107152 and by unrestricted educational gifts from United Therapeutics/Lung Biotechnology LLC.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85037569020&doi=10.1111%2fxen.12345&partnerID=40&md5=8415f9e1e0ddfed530f073e0afd92442; http://hdl.handle.net/10713/10034