PublisherBlackwell Publishing Inc.
MetadataShow full item record
AbstractPresentation of sialic acid (Sia) varies among different tissues and organs within each species, and between species. This diversity has biologically important consequences regarding the recognition of cells by "xeno" antibodies (Neu5Gc vs Neu5Ac). Sia also plays a central role in inflammation by influencing binding of the asialoglycoprotein receptor 1 (ASGR-1), Siglec-1 (Sialoadhesin), and cellular interactions mediated by the selectin, integrin, and galectin receptor families. This review will focus on what is known about basic Sia structure and function in association with xenotransplantation, how changes in sialylation may occur in this context (through desialylation or changes in sialyltransferases), and how this fundamental pathway modulates adhesive and cell activation pathways that appear to be particularly crucial to homeostasis and inflammation for xenografts. Copyright 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
SponsorsThese studies were supported by U19 AI090959, P01 HL107152 and by unrestricted educational gifts from United Therapeutics/Lung Biotechnology LLC.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85037569020&doi=10.1111%2fxen.12345&partnerID=40&md5=8415f9e1e0ddfed530f073e0afd92442; http://hdl.handle.net/10713/10034
- Evolution of sialic acids: Implications in xenotransplant biology.
- Authors: Paul A, Padler-Karavani V
- Issue date: 2018 Nov
- Developmental changes in the level of free and conjugated sialic acids, Neu5Ac, Neu5Gc and KDN in different organs of pig: a LC-MS/MS quantitative analyses.
- Authors: Ji S, Wang F, Chen Y, Yang C, Zhang P, Zhang X, Troy FA 2nd, Wang B
- Issue date: 2017 Feb
- Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation.
- Authors: Naito Y, Takematsu H, Koyama S, Miyake S, Yamamoto H, Fujinawa R, Sugai M, Okuno Y, Tsujimoto G, Yamaji T, Hashimoto Y, Itohara S, Kawasaki T, Suzuki A, Kozutsumi Y
- Issue date: 2007 Apr
- Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition.
- Authors: Khatua B, Ghoshal A, Bhattacharya K, Mandal C, Saha B, Crocker PR, Mandal C
- Issue date: 2010 Feb 5
- Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells.
- Authors: Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, Takematsu H
- Issue date: 2014 Jan 17