Purpose – The purpose of this in vitro study was to compare surface roughness of full contour zirconia restorations produced by additive and subtractive manufacturing Materials and Methods – Full contour restorations were designed using 3Shape Dental System. The stl files were exported and utilized to guide production of all specimens. Zirconia samples were manufactured by two methods – additive manufacturing (n=10) and subtractive manufacturing (n=18). A two-step polishing protocol was used following sintering. All specimens were subject to profilometry to measure average Ra values. Ra values for both groups were compared. Statistical analysis was performed using t-test (p=0.05). Results – The average Ra value for zirconia restorations in the subtractive manufacturing group was 0.35 ±0.07µm while average Ra for additive manufacturing groups was 1.06 ±0.49 µm. Differences were statistically significant (p < 0.00001). Conclusions – Zirconia restorations produced by subtractive manufacturing were significantly smoother than those produced by additive manufacturing even after post-sintering polishing.