The 2025 National Guidelines for Behavioral Health Coordinated System of Crisis Care (2025 National Crisis Guidelines) establishes a framework to transform behavioral health crisis care systems and reduce the impact of substance use and mental illness in communities throughout the United States. Spearheaded by the Substance Abuse and Mental Health Services Administration (SAMHSA), these guidelines aim to provide equitable, accessible, and effective responses to behavioral health crises, and support program design, development, implementation, and continuous quality improvement for behavioral health crisis care throughout the nation. The country’s transition spurs this update to the 988 Suicide & Crisis Lifeline (988 Lifeline), as well as recent progress and emerging needs in the field related to behavioral health crisis system transformation.