Multiparametric Magnetic Resonance Imaging (MP-MRI)/ ultrasound fusion guided biopsy (targeted biopsy) is emerging as an alternative diagnostic tool for Prostate cancer (PCa) in addition to historically used Transrectal Ultrasound-guided (TRUS) biopsy. Echogenicity observed during the fusion of MRI and ultrasound images may be associated with the detection of clinically significant prostate cancer in targeted biopsy of MP-MRI lesions.