Introduction: The objective of this study is to evaluate the effectiveness of a mobile health program targeting seniors with a high risk of hypertension and hypercholesterolemia. Taiwan has gradually become a country with a high percentage of senior citizens. With changes in diet and living habits, the number of seniors suffering from hypertension and hypercholesterolemia is on the increase. In recent years, the use of mobile medical applications for self-healthcare management has been increasing among the senior population. A particular medical application system was evaluated for efficacy in disease prevention, health alerts, and seeking early treatment by enabling participants to measure and control their own health, thus reducing unnecessary medical consultations and contributing to the more efficient use of limited medical resources.