Discussion Synopsis: Jain talks about his experience with several research programs, small and large, that are utilizing these innovative, evidence-based digital tools and resources to conduct patient powered/patient centered precision research. These tools are scientifically proven and have been shown to reduce barriers to clinical research. Jain also talks about how ICTR can build capacity for successful pragmatic clinical trials, investigator-initiated studies, and industry clinical trials, through digital tools, training, and processes. Jain highlights a few research programs such as the NIH All of Us, a large longitudinal study, that has successfully achieved high, multi-year RETENTION through community engagement.