A vast amount of research indicates workplace wellness programs value monetized business outcomes such as costs related to healthcare and productivity. However, some scientists now recommend that employers measure outcomes that are indirectly related to monetary value, including the culture of workplace well-being. These outcomes include measurements of general employee health, health-friendly work environments and employee engagement. This paper discusses how to effectively develop a wellness profile that highlights key health and well-being metrics that are indirectly and directly related to business outcomes. This tool, the Organizational Well-being Profile, can be utilized to communicate important health outcomes around workplace culture to organizational leaders. Please note the findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the Centers for Disease Control and Prevention.