INTRODUCTION: The purpose of this study is to compare the ability of the XP-3D (XP) Shaper (Brasseler USA, Savannah, GA), TRUShape 3D (TS) Conforming Files (Dentsply, Tulsa, OK), and Vortex Blue (VB, Dentsply) files to remove gutta-percha and BC Sealer (BCS, Brasseler USA, Savannah, GA) from root canals, and to compare the time necessary for retreatment. MATERIALS AND METHODS: 36 extracted single-rooted mandibular premolars were instrumented, and obturated with gutta-percha and BCS. The teeth were then retreated with either XP, TS, or VB. The teeth were sectioned and analyzed with a digital microscope at 35x and ImageJ software for the percentage of material on the canal walls. RESULTS: All groups removed obturation material to a similar extent. XP was significantly faster than TS or VB. CONCLUSION: There is no significant difference in the ability of XP, TS, or VB in removing obturation material, however, retreatment with XP is significantly faster.