Purpose: The purpose of this study was to investigate the effect of various anti-caries agents on the surface roughness of three different restorative materials. Materials and Methods: Sixty-four specimens of each material (porcelain, base metal and titanium alloy) were prepared and separated into four groups for soaking in anti-caries agents (Prevident, ACT, chlorhexidine and water). A profilometer was used to measure surface roughness before and after soaking for two years simulated usage. The change in surface roughness for each specimen was calculated. Statistical analysis was completed using a factorial analysis of variance (two-way ANOVA) followed by Tukey's HSD test. A p value ≤0.05 was considered significant. Results: The results demonstrate that there was no significant difference in mean change in surface roughness between the three materials, porcelain, base metal, and titanium. The results further demonstrate that there was a significant difference in mean change in surface roughness between Prevident Dental Rinse and chlorhexidine gluconate. There was no significant difference between water, ACT, and chlorhexidine gluconate. There was also no significant difference between Prevident Dental Rinse, water, and ACT. There was a significant interaction between Prevident Dental Rinse and chlorhexidine within the porcelain samples. Prevident Dental Rinse produced a negative change in surface roughness while chlorhexidine gluconate produced a positive change in surface roughness. Conclusion: Within the limitations of this study, it can be concluded that Prevident Dental Rinse and chlorhexidine gluconate may cause a change in surface roughness of porcelain when used for a period of two years. Prevident Dental Rinse may cause an increase in surface roughness of porcelain while chlorhexidine gluconate may cause a decrease in surface roughness of porcelain.