During the 2009 curricular redesign process, University of Maryland School of Pharmacy faculty members supported the concept that prior to embarking on advanced pharmacy practice experiences, students should know how to apply core knowledge and skills from the pharmaceutical, clinical and health services sciences to real world issues which arise in pharmacy practice and drug development, and be able to articulate and advocate for solutions to therapeutic dilemmas. The objective was to design a course that demonstrates integration and application of scientific principles to solve a therapeutic dilemma, and enhances interaction of faculty across disciplines.