Purpose: This study compared the effect of silver diamine fluoride, acidulated phosphate fluoride and distilled water on the surface roughness of dental ceramics. Materials and Methods: Rectangles of zirconia, lithium disilicate and feldspathic porcelain were treated with 38% SDF, 1.23% APF and distilled water. The surface roughness of each rectangle was measured using a profilometer before and after treatment with the solutions. Multiple comparison of the means among the ceramics and testing solutions was done using 2-Way ANOVA followed by Tukey’s test. P<0.05 was considered significant. Results: APF created the greatest surface roughness compared to SDF and water. Zirconia was unaffected by all solutions. SDF increased the roughness of lithium disilicate and felspathic porcelain, however the results were not statistically significant compared to the control group. Conclusions: With many topical fluoride preparations available, dentists should be aware of their effect on different ceramic systems to prevent surface roughening of restorations.