Endometrial cancer, like numerous other cancer types, exhibits clear racial disparities in the United States for both the incidence and outcomes of the disease. This study seeks to interrogate the role that germline genetic influences, specifically genetic ancestry, may play in contributing to endometrial cancer disparities. This is accomplished by examining the relationship between local ancestry inferences and somatic mutation frequency as well as histologic subtypes. This study highlights three regions along the genome wherein African local ancestry segments were found to significantly correlate with higher tumor mutation burden. A relationship between heterozygous ancestry combinations and increased mutation frequency is also described. Finally, this study identified a single region wherein African local ancestry was found to significantly correlate with a higher incidence of the serous histologic subtype. These findings help to uncover the complex relationships between genetic ancestry and multiple factors underlying the incidence and outcomes of endometrial cancer.