All history begins with a story, and storytelling remains integral to the human condition. From birth (and likely before), we are uniquely attuned to the stories of one another, as even in infancy we strive to mirror vocalizations and respond/echo the utterances of our caregivers. In our brains, narratives trigger frontotemporal response and dopamine release, as well as synchronization efforts with other listeners in the audience. By listening and sharing stories, we can engender compassion, understanding and hope. Storytelling tools are particularly important as we attempt to meaningfully engage and advocate for individuals who too often are marginalized, including those in the HIV/AIDS community. By reflecting on Baltimore and African stories we have been privileged to witness, we hope to encourage time and space for this important and healing tool. Increasing demands are perpetually competing for clinical time, but for optimal patient care, storytelling may be the best tool to establish the foundation of rapport and trust so critically needed for good medical and palliative care.