Plant-derived lipid nanoparticles trap pro-inflammatory cytokines to mitigate Photo & Graphics Group inflammation and improve survival in sepsis
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Abstract
Plant-derived nanoparticles (PDNPs) are recently discovered nano- sized particles that may be isolated from various edible plants, encompassing root plants such as curcumin and ginger, as well as fruits like grapefruit, grape, and lemon. These natural sources contain bioactive components involved in regulating cellular immune responses against pathogenic intrusion and inflammation. The present study describes the isolation, characterization, and development of a novel PDNPs that possesses potent anti-inflammatory characteristics against sepsis. We found that PDNP-treated mice experienced an accelerated recovery, as indicated by a significant reduction in systemic pro- inflammatory cytokines, improved histological index, and increased survival in a therapeutic lipopolysaccharide (LPS)-induced endotoxemia mouse model. This research presents PDNPs as a novel anti-inflammatory PDNP platform with potent pro-inflammatory cytokine sequestration abilities that holds promise for broadly treating inflammatory diseases