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Item DNMTi in combination with PARPi inhibits aberrant WNT/Beta-catenin and Tenascin C pathway signaling, decreasing cancer stemness and metastasis in triple-negative breast cancer(2025-03-28) Tripathi, Kaushlendra; Rutherford, Julia; Stojanovic, Lora; Topper, Michael J.; Baylin, Stephen B.; Nephew, Kenneth P.; Rassool, Feyruz V.Item Inhibition of G protein-coupled proton sensor GPR68 ameliorates acid and LPS-induced lung endothelial dysfunction and acute lung injury(2025-03-23) Ke, Yunbo; Karki, Pratap; Li, Yue; Zhang, Chen-Ou; Promnares, Kamoltip; Williams, Charles H. (Charles Houston); Birukov, Konstantin G.; Hong, Charles C., 1967-; Birukova, Anna A.Item Advancing the Study of Ketogenic Diets in Schizophrenia: Results of a Change.org Support Petition(2025-03-29) Kelly, Deanna L.; Kearns, AnnMarie; Eberhardt, Erich; Vyas, Gopal; Roche, Daniel; Harrington, Valerie; Yuen, Alexa; Glassman, Matthew; Adams, Heather A.; Murray, Sidney; D'Adamo, Christopher; Palmer, ChristopherItem A Randomized Controlled Trial of a Tele-Mentoring Program, Project ECHO, to Increase Clozapine Prescribing(2025-03-29) Kelly, Deanna L.; Hunt, Jared; Vyas, Gopal; Glassman, Matthew; Brown, Clayton H.; Fang, Li Juan; Wehring, Heidi J.; Love, Raymond C.; Weiner, Elaine; Reeves, Gloria; Ehret, Megan J.; Nucifora, Frederick C., Jr.; Buchanan, Robert W.; Lanzkron, Sophie; Barr, Brian; Richardson, Charles M.; Wonodi, Ikwunga; Kearns, AnnMarie; Leistikow, Nicole; Liu, Fang; Adams, Heather A.; Vyas, Rohan; Kreyenbuhl, JulieItem Results of the Clozapine Consultation Center Associated with the State of Maryland Project ECHO Telementoring Program(2025-03-29) Vyas, Gopal; Glassman, Matthew; Wonodi, Ikwunga; Reeves, Gloria; Richardson, Charles M.; Wehring, Heidi J.; Mackowick, Marie; Buchanan, Robert W.; Weiner, Elaine; Liu, Fang; Kearns, AnnMarie; Adams, Heather A.; Love, Raymond; Lanzkron, Sophie; Barr, Brian; Ehret, Megan J.; Davis, Erica; Nucifora , Frederick C.; Hunt, Jared; Letvin, Nicole; Leistikow, Nicole; Pugh, Sharon; Ball, Patricia; Kreyenbuhl, Julie; Kelly, Deanna L.Item Non-Prescriber Participation and Outcomes in a Randomized Controlled Trial of an Extension for Community Healthcare Outcomes (ECHO) Tele-mentoring Program to Increase Clozapine Utilization(2025-03-29) Adams, Heather A.; Kreyenbuhl, Julie; Hunt, Jared; Vyas, Gopal; Glassman, Matthew; Brown, Clayton; Fang, Li Juan; Wehring, Heidi J.; Love, Raymond C.; Weiner, Elaine; Reeves, Gloria; Ehret, Megan J.; Nucifora, Frederick C., Jr.; Buchanan, Robert W.; Lanzkron, Sophie; Barr, Brian; Richardson, Charles M.; Wonodi, Ikwunga; Kearns, AnnMarie; Leistikow, Nicole; Liu, Fang; Vyas, Rohan; Kelly, Deanna L.Item Use of Point of Care Absolute Neutrophil Count Monitoring during a Randomized Controlled Trial of a Tele-Mentoring Program, Project ECHO, to Increase Clozapine Prescribing(2025-03-29) Glassman, Matthew; Hunt, Jared; Vyas, Gopal; Brown, Clayton H.; Fang, Li Juan; Wehring, Heidi J.; Love, Raymond C.; Weiner, Elaine; Reeves, Gloria; Ehret, Megan J.; Nucifora, Frederick C., Jr.; Buchanan, Robert W.; Lanzkron, Sophie; Barr, Brian; Richardson, Charles M.; Wonodi, Ikwunga; Kearns, AnnMarie; Leistikow, Nicole; Liu, Fang; Adams, Heather A.; Vyas, Rohan; Kreyenbuhl, Julie; Kelly, Deanna L.Item Implementation of the Goslings Traffic Light System in a Level IV NICU To Facilitate Communication about Infant Readiness for Interaction(2025-03-16) Aboolatiff, Khateeja; Hussey-Gardner, BrendaItem Mechanisms of SEMA4D Mediated Blood Brain Barrier (BBB) Transmigration(2025-03-10) Sunkara, Anu Deepika; Koltz, Remi; Yu, MinBrain metastasis poses a challenge in cancer treatment due to its prevalence, diagnostic complexities, and the limited efficacy of systemic therapies due to the blood brain barrier (BBB). Previous work in our lab utilized patient-derived Circulating Tumor Cell (CTC) lines established from the peripheral blood of patients with metastatic luminal breast cancers to investigate the molecular features that allow a subset of CTCs to adapt and grow in the brain. This study identified Semaphorin 4D (SEMA4D), a transmembrane receptor that facilitates BBB transmigration, both in vitro and in vivo, through its interaction with the Plexin B1 (PLXNB1) receptor. Together with oncogene MYC, SEMA4D facilitates the colonization of the brain and promotes brain metastasis of CTCs. In this study, we propose investigating the hypothesis that the reverse signaling via the cytoplasmic region of SEMA4D activates the Yes Associated Protein (YAP) pathway, facilitating BBB transmigration. Our data shows that truncating the cytoplasmic region of SEMA4D (deleting the PDZ binding domain) in the BT474 HER2 positive cell line reduces BBB transmigration. In addition, cells that are overexpressed with SEMA4D showed nuclear localization of YAP via immunofluorescence. Hence, using patient-derived CTC cultures and a model system of breast cancer cell lines we aim to elucidate SEMA4D’s link to YAP signaling and the mechanism of BBB transmigration. Understanding the mechanisms underlying metastatic invasion through the BBB is crucial for developing targeted interventions in the future.Item Factors Associated with PrEP Uptake, Persistence, and Adherence Among Incarcerated People in Zambia(2025-03-09) Lindsay, Brianna; Claassen, Cassidy W.; Siyambango, Muyunda; Mwango, Linah K.; Baumhart, Caitlin; Nyirongo, Nasho; Mujansi, Morley; Moonga, Clement; Muchanga, Godfrey; Bwalya, Chiti; Gandhi, Monica; Musheke, Maurice; Herce, Michael E.Item Comparative Efficacy of Dupilumab & Standard of Care Treatments for Eosinophilic Esophagitis in Pediatric Patients(2025-03-01) Jung, Myung Sun; Waddell, Jaylyn; Hong, Jennifer; Kewalramani, AnuItem Impact of an interactive, case-based Pediatric Gastroenterology & Nutrition Curriculum on general pediatric resident competency and knowledge retention(2025-02-22) Eslami, Katayoun; Giudice, Erin L.; Calderon, Lina Diaz; Racherla, Vandana; Donohue, KatelynItem Survey of Disordered Eating Behaviors in Resident Physicians(2025-02-22) Khan, Maisha; Sethumadhavan , Aparna; Carter, RebeccaItem Caregiver Assessment of Tackle Football (TFB) Among School Aged Boys in an Urban Photo & Graphics Group Environment(2025-02-23) Dalo, Juan; Pardes, Zachary; Ikheloa, Eseigboria; Feigelman, SusanBackground: Increasing media attention has highlighted injuries associated with tackle football (TFB) with special attention to head injuries and long-term consequences in professional players. Sequelae from concussions may be more severe in children who play TFB. In the literature, parents, coaches, and medical professionals describe benefits associated with playing team sports. Therefore, caregivers may have ambivalent feelings regarding allowing their children to play. Recent studies, using regional and national samples, have elucidated some of these parental perceptions. However, few studies have focused on urban populations. Methods: A semi-structured interview, based on a Center for Disease Control (CDC) survey (Waltzman, 2024) was given to a convenience sample of caregivers in the University of Maryland Pediatrics at Midtown practice. Caregivers were asked to complete the written questionnaire and then were queried for additional thoughts on health beliefs regarding youth TFB. Demographics were tabulated comparisons were made between groups. Survey items were sorted according to the Health Belief Model (HBM) dimensions: susceptibility, severity, benefits, barriers, self-efficacy, and cue-to-action. Results: 45 questionnaires have been completed. The following data compares our results to the CDC study. Most respondents were female (80% vs. 50%). 91% were non-Hispanic black (vs. 9%). In the current study, 87% were < 44 years (vs. 33%). Child’s insurance was mostly Medicaid (84%). 82% were strongly or somewhat fans of American football (vs. 59%). When asked “When is a good age for kids to start playing tackle football”, 87% responded before high school (vs. 45%). However, 91% were very or somewhat concerned about the safety of kids playing tackle football (vs. 87%). Additional data will be presented showing similarities and differences in the HBM perceptions in these two groups. Conclusions: Prior national studies have described parents’ perceptions about youth TFB. We found almost all caregivers were concerned about safety yet still felt that children can start playing prior to high school. In this local study, caregivers’ perceptions had similarities and differences regarding the pros and cons of playing TFB when compared to a national study. Data collection is ongoing.Item Assessing Dietary Quality in Older Veterans: A Comparison of Dietary Intake Tools(2024-11-20) Patel, Sanam; Giffuni, Jamie; Beans, Jeffrey; Dennis, ElizabethItem Intravascular Lipoma of the Left Jugular Subclavian Vein Confluence(2025-02-18) Jreij, Georges; Plant, Joshua; Madabhushi , Vashisht; Dunlap, Eleanor; Tulshyan, Antariksh; Nagarsheth, KhanjanItem Caregiver Access to Healthcare and Undiagnosed Caregiver Depression(2025-02-15) Joshi, Sama; Deshmukh, Sanyukta; Owolabi, Adebola; Rucker, AlexandraItem Heel Pain in a High Level Collegiate Football Player(2025-02-15) Elliott, Katlyn; Cothran, ValerieItem Atraumatic Unilateral Knee Swelling in a Squash Athlete(2025-02-15) Perlman, JoshuaItem Rehabilitation of a NCAA Division I Runner Following a Sesamoidectomy Secondary to Avascular Necrosis: A Case Report(2025-02-13) VanDuLuitgaarden, Jeremy; Shipley, Jason; Scheve, Matthew; Film, Roy